In 1997, the first sequencing of pieces of DNA extracted from a Neanderthal-type specimen was published in the journal Cell, by a team of scientists led by Svent Pääbo. In the groundbreaking study, mitochondrial DNA was amplified from a sample (a small piece of the arm bone) from the first Neanderthal man found (1856). “The Neanderthal sequence falls outside the variation of modern humans.” The results suggested that from their common origin (“African Eve”), Neanderthals split off from humans a little over 550,000 years ago as a separate species and “went extinct without contributing mtDNA to modern humans.” (Using population models, Pääbo, more recently estimated that Neanderthals could have contributed up to 25% of their genetic makeup to modern human, but likely much less.)«[Ref: Cell (11 Jul 1997), 90, No.1, 19-30.]